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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Ribothymidin</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable infobox float-right" id="Vorlage_Infobox_Chemikalie" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Chemikalie">
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Strukturformel
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Allgemeines
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<td style="width:33%;">Name
</td>
<td>Ribothymidin
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<td>Andere Namen
</td>
<td>
<ul><li>T (Kurzcode), m<sup>5</sup>U (Kurzcode)</li>
<li>5-Methyluridin</li>
<li>1-β-<small>D</small>-Ribofuranosyl-5-methylpyrimidin-2,4-dion</li>
<li>1-[(2<i>R</i>,3<i>R</i>,4<i>S</i>,5<i>R</i>)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2,4-dion</li>
<li>Thyminribosid</li></ul>
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<td><a href="Summenformel" title="Summenformel">Summenformel</a>
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<td>C<sub>10</sub>H<sub>14</sub>N<sub>2</sub>O<sub>6</sub>
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<tr>
<th colspan="2" style="background:#FFDEAD; color:#202122;">Externe Identifikatoren/Datenbanken
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<td colspan="2" style="padding:0;">
<table class="mw-collapsible mw-collapsed wikitable" data-expandtext="+" data-collapsetext="−" style="border-top:none; margin:-1px; width:calc(100% + 2px);">
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<td style="width:33%;"><a href="CAS-Nummer" title="CAS-Nummer">CAS-Nummer</a>
</td>
<td><span title="Untervorlage eingebunden: CASRN"></span><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1463-10-1">1463-10-1</a><span class="editoronly" style="display:none;"></span>
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<td style="background:#FFDEAD; color:#202122; border-top:1px solid #FFDEAD; padding:0.2em 0; vertical-align:bottom; width:5%;">
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<td><a href="EG-Nummer" title="EG-Nummer">EG-Nummer</a>
</td>
<td colspan="2">215-973-9
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<td><a href="Europ%C3%A4ische_Chemikalienagentur" title="Europäische Chemikalienagentur">ECHA</a>-InfoCard
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://www.echa.europa.eu/de/substance-information/-/substanceinfo/100.014.522">100.014.522</a>
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<td><a href="PubChem" title="PubChem">PubChem</a>
</td>
<td colspan="2"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/445408">445408</a>
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<td style="border-right:1px solid #a2a9b1;"><a href="Wikidata" title="Wikidata">Wikidata</a>
</td>
<td colspan="2"><a href="https://www.wikidata.org/wiki/Q425078" class="extiw external" title="d:Q425078">Q425078</a>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Eigenschaften
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<td><a href="Molare_Masse" title="Molare Masse">Molare Masse</a>
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<td>258,23 g·<a href="Mol" title="Mol">mol</a><sup>−1</sup>
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<td><a href="Aggregatzustand" title="Aggregatzustand">Aggregatzustand</a>
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<td>
<p>fest
</p>
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<td><a href="Schmelzpunkt" title="Schmelzpunkt">Schmelzpunkt</a>
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<p>183–184 <a href="Grad_Celsius" title="Grad Celsius">°C</a><sup id="cite_ref-ALDRICH_1-0" class="reference"><a href="#cite_note-ALDRICH-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
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<th colspan="2" style="background:#FFDEAD; color:#202122;">Sicherheitshinweise
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<td colspan="2">
<table cellspacing="0" cellpadding="2" style="width:100%;">
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<td colspan="2" style="text-align:center"><b><a href="Global_harmonisiertes_System_zur_Einstufung_und_Kennzeichnung_von_Chemikalien" title="Global harmonisiertes System zur Einstufung und Kennzeichnung von Chemikalien">GHS-Gefahrstoffkennzeichnung</a></b><sup id="cite_ref-ALDRICH_1-1" class="reference"><a href="#cite_note-ALDRICH-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
<table class="hintergrundfarbe-neutral" style="text-align:center; margin-left:auto; margin-right:auto; display:flex; justify-content:center;">
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<td><i>keine GHS-Piktogramme</i>
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<p>
</p>
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<td rowspan="2" width="33%" style="border-top:1px #A7A7A7 dashed; border-right:1px #A7A7A7 dashed;"><a href="H-_und_P-S%C3%A4tze" title="H- und P-Sätze">H- und P-Sätze</a>
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<td style="border-top:1px #A7A7A7 dashed;">H: <span title="Untervorlage eingebunden: H-Sätze"></span><i>keine H-Sätze</i>
</td></tr>
<tr>
<td style="border-top:1px #A7A7A7 dashed;">P: <span title="Untervorlage eingebunden: P-Sätze"></span><i>keine P-Sätze</i><sup id="cite_ref-ALDRICH_1-2" class="reference"><a href="#cite_note-ALDRICH-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</td></tr>
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</td></tr>
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<td colspan="2" style="background:#FFDEAD; color:#202122; font-size:80%; text-align:center; line-height:150%; padding:.25em;">Wenn nicht anders vermerkt, gelten die angegebenen Daten bei <a href="Standardbedingungen" title="Standardbedingungen">Standardbedingungen</a> (0 °C, 1000 hPa).
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Ribothymidin</b> ist ein eher seltenes <a href="Nukleosid" class="mw-redirect" title="Nukleosid">Nukleosid</a>, bei dem die <a href="Nukleinbase" class="mw-redirect" title="Nukleinbase">Nukleinbase</a> <a href="Thymin" title="Thymin">Thymin</a> an die <a href="Pentose" class="mw-redirect" title="Pentose">Pentose</a> <a href="Ribose" title="Ribose">β-<small>D</small>-Ribofuranose</a> gebunden ist. Dieses Nukleosid wird auch als <b>5-Methyluridin</b> bezeichnet und kommt in <a href="Ribonukleins%C3%A4ure" title="Ribonukleinsäure">Ribonukleinsäuren</a> wie <a href="RRNA" class="mw-redirect" title="RRNA">rRNA</a> und <a href="TRNA" title="TRNA">tRNA</a> vor.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Insbesondere ist es ein charakteristisches Bauelement in der <a href="TRNA#Pseudouridinschleife" title="TRNA">TΨC-Schleife</a> von tRNA.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p><p>Ribothymidin wird auch kurz <i>Thymidin</i> genannt (Kürzel: T); das standardmäßig in der <a href="DNA" class="mw-redirect" title="DNA">DNA</a> vorkommende Analogon mit <a href="Desoxyribose" title="Desoxyribose">Desoxyribose</a> ist das <a href="Desoxythymidin" title="Desoxythymidin">Desoxythymidin</a> (Kürzel: dT).
</p>
<dl><dd></dd></dl>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-ALDRICH-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-ALDRICH_1-0">a</a></sup> <sup><a href="#cite_ref-ALDRICH_1-1">b</a></sup> <sup><a href="#cite_ref-ALDRICH_1-2">c</a></sup></span> <span class="reference-text">Datenblatt <span style="font-style:italic;"><a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/catalog/product/ALDRICH/286699">5-Methyluridin</a></span> bei <a href="Sigma-Aldrich" title="Sigma-Aldrich">Sigma-Aldrich</a>, abgerufen am 11. März 2011 (<a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/DE/de/sds/ALDRICH/286699?userType=anonymous">PDF</a>).<span class="editoronly" style="display:none;"></span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: „Summary: the modified nucleosides of RNA“, <i><a href="Nucleic_Acids_Research" title="Nucleic Acids Research">Nucleic Acids Research</a></i>, <b>1994</b>, <i>22</i> (12), S. 2183–2196 (<a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1093/nar%2F22.12.2183">10.1093/nar/22.12.2183</a></span>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC523672/">PMC 523672</a> (freier Volltext), <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7518580?dopt=Abstract">PMID 7518580</a>).</span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><a href="Robert_W._Holley" title="Robert W. Holley">Robert W. Holley</a>, Jean Apgar, George A. Everett, James T. Madison, Mark Marquisee, Susan H. Merrill, John Robert Penswick, Ada Zamir: „Structure of a Ribonucleic Acid“, <i><a href="Science" title="Science">Science</a></i>, <b>1965</b>, <i>147</i>, S. 1462–1465 (<a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1126/science.147.3664.1462">10.1126/science.147.3664.1462</a></span>).</span>
</li>
</ol>
<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>
<ul><li>Eintrag zu <span style="font-style:italic;"><a rel="nofollow" class="external text" href="http://www.hmdb.ca/metabolites/HMDB00884">Ribothymidine</a></span> in der <i>Human Metabolome Database (HMDB)</i>, abgerufen am 24. September 2013.<span class="editoronly" style="display:none;"></span></li>
<li>Modification Summary von <span style="font-style:italic;"><a rel="nofollow" class="external text" href="http://modomics.genesilico.pl/modifications/m5U">5-methyluridine</a></span> in der <i>Modomics</i>-Datenbank, abgerufen am 14. Januar 2014.<span class="editoronly" style="display:none;"></span></li></ul></div><!--htdig_noindex--><div><div class="zim-footer">
Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2021-05-27" href="https://de.wikipedia.org/wiki/?title=Ribothymidin&oldid=212412196">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.
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